Behavioral and Functional Neuroscience Laboratory–

From Genotype to Phenotype

From Genotype to Phenotype
Behavioral Experiment Task Parameter studied Brain Regions Believed to be Involved, but not Limited to Reference(s)
Sensory and Motor  function Activity Chamber General motor activity in novel environment Cerebellum, Cerebral cortex, Septum, Striatum, Thalamic reticular nucleus, Spinal cord, Hippocampus (Deacon et al., 2002; Viggiano, 2008)
Phenotyper General motor activity in home cage condition Hippocampus, Prefrontal Cortex. Striatum, cerebral cortex, Cerebellum, Brain stem, Spinal cord (Takakusaki, 2008)
Catwalk Gait Analysis Striatum, Cerebral cortex, Cerebellum, Brain stem, Spinal cord (Takakusaki, 2008)
Rotor-Rod Performance Test Motor function, balance and coordination    
Grip Strength Forelimb muscular strength assessment    
Open Field Activity test General motor activity in novel environment Cerebellum, Cerebral cortex, Septum, Striatum, Thalamic reticular nucleus, Spinal cord, Hippocampus  
Foot Fault Forelimb function    
Wire hang Test Neuromuscular function    
Cylinder Test Forelimb asymmetry & akinesia assessment    
Hot Plate Test Nociceptive effect    
Garcia Neurological Test Garcia neurological test    
28-point Neurological Scoring Post-ischemic motor & behavioral deficit test    
Vibrissae-evoked forelimb placing Test Forelimb asymmetry test Cortex & Striatum  
Learning and Memory T-maze Spontaneous Alternation Spatial working emory Hippocampus (Devenport et al., 1988; Gerlai, 1998; Johnson et al., 1977)
Y-maze Spontaneous Alternation
Place learning in Intellicage Spatial learning and memory retrieval in home cage condition Hippocampus (Galsworthy et al., 2005)
Place Avoidance in Intellicage Spatial learning and memory retrieval in home cage condition Hippocampus, amygdala (Galsworthy et al., 2005)
Satellite box exploration in Intellicage Exploratory of novel environment in home cage condition Hippocampus (Galsworthy et al., 2005)
DMP Water Maze Spatial working/episodic-like memory Hippocampus (Steele and Morris, 1999)
Morris Water Maze Spatial learning and memory Hippocampus  
Contextual and tone-cued Fear Conditioning Pavlovian (associative) learning Hippocampus and amygdala (Anagnostaras et al., 1999; Kim and Fanselow, 1992)
Active/Passive Avoidance Natural tendency of avoidance    
Startle response & Pre-pulse Inhibition Arousal behavior    
Elevated Plus maze Anxiety-like behavior    
Radial Arm Maze Spatial learning task Hippocampus & Pre-frontal cortex  
Conditioned place preference Place/Spatial learning task    
Novel Object Recognition Spatial displacement & recognition memory Hippocampus & Pre-frontal cortex

(Fernandez and Garner, 2007)
Barnes Maze Spatial working/episodic-like memory Hippocampus  
Visual Acuity test Vision-based performance & learning    
Social Interaction Sociability in 3-Chambered test Sociability Amygdala and prefrontal Cortex (Lim and Young, 2006; Young et al., 2005)
Social Novelty in 3-Chambered test Social novelty
2-Trial Social Memory in Home Cage Social memory Medial amygdala and lateral septum
5-Trial Social Memory Social memory
Vision-based performance & learning Social dominance/withdrawal behavior    
Ultrasonic vocalization Detection of communication deficit    
Olfactory Habituation/Dishabituation Olfactory memory formation    

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